Image-guided cancer ablation involves the placement of needles into a tumor, which is then destroyed using extreme heat (microwave or radiofrequency) or extreme cold (cryoablation) to directly kill the cancer.
In typical immune-vaccinations, the disease-causing agent is killed or weakened and injected into the body. Ablation results in the killing of the tumor within the body, leaving pieces of cancer that can potentially be recognized by the immune system.
Studies have demonstrated that ablation has the potential to be more effective than surgery for the treatment of local tumors. However, for most cancer patients, it is the spread of the tumor from the original location (“metastases”) that ultimately results in their death. For metastatic disease, systemic therapies, such as chemotherapy, have been the only option for treatment, and overall, they have not been as effective as desired.
The problem with most typical cancer therapies is that they “poison” or treat the whole body and do nothing to teach the body how to fight cancer in the future. Current treatments are often ineffective in ridding the body of all cancer. Once the medicines are stopped, or resistance develops, the cancer progresses again. The key to cancer therapy is to teach the immune system how to fight the cancer.
The immune system learns and has memory. This is why you can be vaccinated against something now and fight the disease off when exposed to it many years, even decades later. This is how the combination of immunotherapy and ablation works. The ablation kills the tumor, leaving dead pieces and releasing substances to stimulate the immune response. Immunotherapy drugs such as Yervoy, Opdivo, and Keytruda take the brakes off the immune system, allowing it to attack the dead tumor. This trains the immune system to attack cancer in other locations as well.
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