Immunotherapy has proven effective in fighting many cancers, including melanoma and breast cancer. It is now recognized that cancer can use the immune system to protect itself, shutting off the part of the immune system that would attack it. The identification of receptors used by cancer cells to shut off the immune system has allowed the development of effective immune therapies. When these receptors are blocked, the immune system has the opportunity to recognize the cancer and learn to attack it. The main drugs currently available are CTLA-4 inhibitors (Yervoy) and PD-1 inhibitors (Opdivo and Keytruda). The FDA has approved these therapies for melanoma. Opdivo is also approved for non-small cell lung cancer.
Is an technique a combination of immunotherapy medications directly into the tumor to activate the immune system to attack cancer cells, when the immunotherapy is administered, the body responds by recruiting immune cell such as T lymphocytes which are essential for destroying tumor cells.
These immune cells activated locally with the tumor, recognize abnormal proteins present in the cancer cells.
Once T lymphocytes detect these signals, they begin attacking cancer cells inside the tumor and throughout the body if the cancer has spread.
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